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Trichloroacetic acid: Versatile applications and important safety aspects

by Biolaboratorium 25 Sep 2025

Trichloroacetic acid, also known as TCA, is a chemical compound that plays an important role in a wide range of industries and applications. In this blog post, we will take a closer look at the properties, industrial applications, and safety aspects of handling this substance.

What is trichloroacetic acid?

Trichloroacetic acid is a colorless, crystalline compound with the chemical formula CCl3COOH. It belongs to the group of carboxylic acids and is characterized by its high reactivity and solubility properties. Trichloroacetic acid is highly soluble in water, alcohol, and other polar solvents.

Physical and chemical properties

Trichloroacetic acid has a melting point of 57.5 °C and a boiling point of 195.5 °C. It is a strong acid with a pKa value of 0.66, meaning it dissociates almost completely in aqueous solution. Due to its high reactivity, trichloroacetic acid can react with many organic and inorganic compounds.

Industrial applications of trichloroacetic acid

Trichloroacetic acid is used in a wide range of industries. Some of the most important application areas are:

Chemical industry

In the chemical industry, trichloroacetic acid is used as a starting material for the production of other chemical compounds, such as chloral, chloroform, and carbon tetrachloride.

Medicine and Pharmacy

In medicine and pharmacy, trichloroacetic acid is used as a cauterizing agent in dermatology to treat warts, genital warts, and other skin lesions. It is also used in protein analytics to precipitate proteins from solutions.

Food Industry

In the food industry, trichloroacetic acid is used as a reagent in analytics, for example to determine proteins in food.

Textile Finishing

In textile finishing, trichloroacetic acid serves as a catalyst in the production of synthetic fibers such as polyacrylonitrile.

Wood Industry

In the wood industry, trichloroacetic acid is used for impregnating and preserving wood.

Electronics Industry

In the electronics industry, trichloroacetic acid is used for cleaning and degreasing metal surfaces.

Safety Aspects in Handling Trichloroacetic Acid

Although trichloroacetic acid is versatile, handling this substance requires special precautions. Trichloroacetic acid is corrosive and can cause severe burns upon contact with skin or eyes. Therefore, it is important to wear appropriate protective equipment such as gloves, safety glasses, and protective clothing.

Storage and Transport

Trichloroacetic acid must be stored in well-ventilated rooms and separated from other chemicals. During transport, safe packaging and labeling must be ensured.

Disposal

Waste containing trichloroacetic acid must be disposed of properly. Disposal via the sewage system is not permitted, as trichloroacetic acid can be toxic to aquatic organisms.

First Aid Measures

In case of contact with trichloroacetic acid, first aid measures must be taken immediately. Affected skin areas should be rinsed with plenty of water; in case of eye contact, ophthalmological treatment is required.

Conclusion

Trichloroacetic acid is a versatile chemical compound with numerous industrial applications. However, handling this substance requires special safety measures as it can be corrosive and harmful to health. By adhering to safety regulations and appropriate protective measures, trichloroacetic acid can be used safely and efficiently in various industrial sectors.

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