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Propionic Acid – Mode of Action and Fields of Application

by Biolaboratorium 28 Jan 2026
Propionsäure – Wirkungsweise und Anwendungsgebiete

Propionic acid is an important organic acid that is widely found in nature and has diverse applications. In this blog post, we want to take a closer look at the mode of action and the possible uses of this useful compound.

What is Propionic Acid?

Propionic acid, also called propanoic acid, is a saturated, aliphatic carboxylic acid with the chemical formula CH3CH2COOH. It belongs to the group of short-chain fatty acids and occurs naturally in many foods such as cheese, butter, bread, and vegetables.

Propionic acid was first discovered in 1844 by the German chemist Hermann Kolbe, who isolated it from propionic acid ester. Since then, it has developed into an important base material in the chemical industry.

Mode of Action and Properties

Propionic acid is a colorless, pungent-smelling liquid that is soluble in water, alcohol, and ether. With a melting point of about +81°C and a boiling point of about +141°C, it is classified among the medium-volatility acids.

The acid strength of propionic acid is moderate, with a pKa value of about 4.9. This means that it is partially dissociated in aqueous solution and thus causes a slightly acidic pH value.

Propionic acid acts antimicrobially, i.e., it inhibits the growth and reproduction of bacteria, yeasts, and molds. This effect is based on the acid's ability to penetrate cells and lower the pH there. This disrupts vital metabolic processes of the microorganisms.

Fields of Application of Propionic Acid

Due to its diverse properties, propionic acid is used in numerous industries:

Food Industry

In the food industry, propionic acid is used as a natural preservative. It extends the shelf life of bread, baked goods, cheese, and other products by inhibiting the growth of molds and bacteria. Furthermore, propionic acid can be used for acidification and flavor enhancement.

Pharmacy and Cosmetics

In pharmacy and cosmetics, propionic acid finds application as an active ingredient against acne and other skin conditions. Due to its antimicrobial properties, it is used in creams, lotions, and gels. It can also serve as a preservative in cosmetic products.

Agriculture

In agriculture, propionic acid is used as a feed additive to improve the digestion and utilization of nutrients in livestock. It can also be used for preserving silage.

Chemical Industry

In the chemical industry, propionic acid serves as a starting material for the production of esters, amides, and other organic compounds. It is used in the production of plastics, paints, adhesives, and lubricants.

Other Applications

Furthermore, propionic acid is used in the textile, paper, and leather industries. It can also be employed in cleaning agents, disinfectants, and antifreeze agents.

Conclusion

Propionic acid is a versatile organic acid with numerous possible applications. Its antimicrobial effect, preservative properties, and chemical reactivity make it a valuable base material in industry. Whether in foods, pharmaceuticals, agriculture, or chemistry - propionic acid is a useful and important component of our daily lives.

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